Yingcheng (Charles) Wu 吴英成

About

Research directions

Publications

AI for scientific discovery

• Discovery Foundation Models: Toward open-ended discovery intelligence L. Yang, Z. Yin, Y. Wu* arXiv 2026PaperGitHub
• ScienceBuddy: Recursive-in-recursive self-improvement for interactive scientific agents S. Xue#, … Z. Yin*, Y. Wu*, L. Yang* arXiv 2026PaperWebsiteCode
• An immune world model for multiscale forecasting and therapeutic hypothesis generation T. Cui#, … P. A. Heng*, L. Yang*, Z. Yin*, Y. Wu* arXiv 2026Paper
• RSI-Anything: Unlocking recursive self-improvement with world models T. Cui, … P. A. Heng*, Z. Yin*, Y. Wu*, L. Yang* arXiv 2026PaperCode
• OpenIO: An open framework for AI-native immunotherapy Y. Wu, … S. Zheng, Q. Gao Cancer Cell 2026Project

More recent preprints

• GALILEO: Embodied AI scientist for autonomous therapeutic discovery in dynamic membrane systems N. Jiang, … Y. Wu*, Q. Gao* bioRxiv 2026Paper
• MedGenesis: Toward a world model for autonomous clinical and translational research H. Xiao, … Y. Wu*, Q. Gao* medRxiv 2026Paper
• MedOS: AI-XR-Cobot world model for clinical perception and action Y. C. Wu, … M. Wang*, L. Cong* medRxiv 2026PaperProject
• ScienceIDE: Turning world’s scientific codebase into agent learnable environments H. Geng, … Z. Yin*, Y. Wu*, L. Yang* arXiv 2026PaperProjectCode
• JEPA-Anything: Learning predictive models across different worlds T. Cui, … Y. Wu*, Z. Yin*, L. Yang* arXiv 2026PaperCode
• Recursive experiential–working memory evolution for long-horizon agent harnesses Z. Yu, Y. Wu, … L. Yang arXiv 2026Paper
• PAST-Bench: Benchmarking the foundations of recursive self-improvement in personal agents S. Xue#, … Y. Wu, … M. Wang*, L. Yang* arXiv 2026Paper
• Toward skill-native LLMs: Skill entropy for benchmarking and training long-horizon reasoning Y. He, … Y. Wu, … S. Arora arXiv 2026PaperCode
• OriGene: A self-evolving virtual disease biologist automating therapeutic target discovery Z. Zhang#, Z. Qiu#, Y. Wu#, … S. Zheng bioRxiv 2025Paper

Cancer Research

• A tumor-to-brainstem circuit drives sympathetic outflow and myelopoiesis in BAP1-deficient cancers X. Yang#, C. Yang#, Y. Wu#, … J. Fan, C. Wang, Q. Gao Science Accepted
• Neutrophil profiling illuminates anti-tumor antigen-presenting potency Y. Wu#, J. Ma#, … J. Fan, X. Zhang, Q. Gao Cell 2024Paper
• A blueprint for tumor-infiltrating B cells across human cancers J. Ma#, Y. Wu#, … J. Fan, X. Zhang, Q. Gao Science 2024Paper
• Amplifying antigen-induced cellular responses with proximity labelling S. Li#, Y. Meng#, Z. Wang#, Y. Wu#, … Q. Gao, S. Han Nature 2025Paper

More papers

• Tumor-host cometabolism collaborates to shape cancer immunity Y. Wu, Q. Zou, P. Jiang, Q. Gao Cancer Discovery 2024
• Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level Y. Wu#, S. Yang#, … Q. Gao Cancer Discovery 2022Paper

# equal contribution, * corresponding author. Full list on Google Scholar.

Selected honors

• Invited Young Scientist, Lindau Nobel Laureate Meetings
• Sidney & Joan Pestka Award, International Cytokine & Interferon Society
• Forbes Global Alliance Young Leader
• WAIC Yunfan Rising Star Award 世界人工智能大会明日之星
• World’s Top 2% Scientists, Stanford
• Shanghai Science Rising Star Award 上海市明日科技之星